The Seagulls went into the winter break in fine form, without losing a game in seven matches, and will be hopeful of continuing their positive momentum with a big result over Antonio Conte's side.
The last time the two sides faced each other, over a year ago, Brighton defeated Spurs 1-0 thanks to Leandro Trossard's first-half goal.
Meanwhile, youngster Odel Offiah put pen to paper on a new deal earlier in the week, which will see him stay with the club until at least 2024.
Discussing his decision, the 19-year-old said: “I am delighted to sign the new contract, it’s a good feeling to be recognised for the work that I’ve put in since I joined.
“It’s a great club to be at and there’s a real pathway for young players to make their breakthrough.
“I’ve tried to build on everything I have done so far, I made my debut and then my first start this season, so I am really happy with the opportunities I have had.
“I know I need to keep working hard to get another opportunity and being given the chance to train with the first team means that I get to show the first team staff what I am about. I want to keep progressing.”
Take a look at all the latest stories from the Premier League, as the reaction to Monday's enthralling transfer deadline day continues:
1. Hammers miss out on Zapata
West Ham United are believed to have missed out on a late deadline day swoop for Atalanta striker Duvan Zapata. The Hammers were said to have made a late loan offer for the Colombia international, but failed to get the deal over the line. (Sky Sports News) Photo: MARCO BERTORELLO
2. Magpies to return for Ruiz
Newcastle United look set to battle the likes of Man Utd and Liverpool to sign Napoli midfielder Fabian Ruiz in the summer. The Magpies are a keen admirer of the Spain international, and are said to have had a £33m offer turned down on deadline day. (Corriere dello Sport) Photo: Alessandro Sabattini
3. Clark could be axed from squad
Newcastle United are said to be preparing to axe defender Ciaran Clark from their 25-man squad. The Magpies need to cut three players from their current squad to make room for their five new January signings, and Clarke is believed to be a prime candidate. (Football Insider) Photo: Stu Forster
4. Reds still hopeful of signing Carvalho
Liverpool said said to be "confident" of landing target Fabio Carvalho in the summer, despite missing out on the Fulham sensation on deadline day. They'll now look to agree a pre-contract with the player before completing the deal at the end of the current campaign. (Sky Sports) Photo: Clive Rose