The A27 was partially blocked eastbound after a collision at Hammerpot, near Angmering, around 1.30pm on Thursday (April 11).
Sussex Police said the collision, near the Hammerpot roundabout. involved a silver Kia and a blue Peugeot 107.
A spokesperson added: “There were no reported serious injuries and a temporary closure was in place.”
South East Coast Ambulance (SECAmb) crews joined police officers at the scene.
A spokesperson said: “SECAmb were called just before 2pm to reports of a road traffic collision involving two vehicles on the A27 near Arundel Road.
"Crews arrived on scene and one person was taken to Worthing Hospital for further medical treatment.”